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Product Profile
Product NameWHSC2 AntibodyAntibody TypePrimary AntibodiesProduct descriptionThis gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
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ImmunogenThis WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.
Key Feature
ClonalityPolyclonalIsotypeIgHost SpeciesRabbitTested ApplicationsWB
For WB starting dilution is: 1:1000:
Species ReactivityHuman
Concentration1 mg/mlPurificationAffinity purified
Target Information
Gene SymbolNELFAAlternative NamesNegative elongation factor A
NELF-A
Wolf-Hirschhorn syndrome candidate 2 protein
NELFA
WHSC2
More Molecular Weight(MW)57 kDaSequence SimilaritiesPredicted species reactivity based on immunogen sequence: Mouse
Database Links
Entrez Gene7469Protein AccessionQ9H3P2
Application
ApplicationWestern blot analysis in NCI-H460 cell line lysates (35ug/lane).Application NotesFor WB starting dilution is: 1:1000:
Additional Information
FormLiquidStorage InstructionsStore at 4˚C for three months and -20˚C新手炒股配资, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.Storage BufferSupplied in PBS with 0.09% (W/V) sodium azide.
发布于:云南省